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Surface enhanced Raman spectroscopy (SERS) coupled with chemometric methods, such as adaptive iteratively reweighted penalized least squares (AIR-PLS), wavelet transform, and least squares support vector machine (LSSVM), was investigated to realize the rapid detection and identifi cation of ractopamine (RAC) and clenbuterol hydrochloride (CL) residues in pork. Growth in food animals include ractopamine, Clenbuterol, Paylean and Optaflex. Ractopamine was approved by the FDA in 1999 for use in finishing swine and 2003 for finishing cattle. Commercial names of ractopamine (normallyexist as ractopamine hydrochloride) are Paylean for swine and Optaflexx for cattle (2). Ractopamine is not the only beta agonist in use in animals and under a safety cloud. Clenbuterol, a cousin drug to ractopamine causes such adrenalin effects in humans it was banned in Olympics sports. Cyclist Alberto Contador failed a Tour de France anti-doping test in 2010 for levels of clenbuterol which he said he got from eating meat. Detection rates of β-agonists decreased in the following order: Clenbuterol (6. 37%) > Ractopamine (2. 62%) > Salbutamol (2. The β-agonists levels were higher for pork than for beef and lamb. Detection of Ractopamine and Clenbuterol Hydrochloride Residues in Pork Using Surface Enhanced Raman Spectroscopy – NASA/ADS. A simple, sensitive and reproducible gas chromatographic–mass spectrometric method was developed for monitoring ractopamine (RAC) and clenbuterol (CLB) in feeds Ambroxol mas clenbuterol dosis adulto
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